Reassessment of the Clinical Significance of the Demarcation Line in the Corneal Stroma in Crosslinking

Purpose: To consider the clinical significance and features of formation a demarcation line in corneal stroma with various methods crosslinking.
 Materials Methods: Literature data on evaluation effectiveness crosslinking by were analyzed. The during prophylactic therapeutic excimer laser was studied after photorefractive operations, keratoconus other pathologies cornea (168 operations).
 Results: With crosslinking, including depth varied from 1/3 to 2/3 thickness. It noted that saturation 0.25% solution riboflavin is accompanied large increasing effect optical density above at shallower its occurrence. severity aseptic inflammatory reaction affected density, shape, intensity, stroma. In some cases, when saturated immediately refractive keratoablation without additional UV irradiation. revealed processes participation activation radiation. study showed assessment not an indicator photochemical process number crosslinks formed stroma.
 Conclusion: Based severity, shape line, it possible judge stroma, which predetermine strength properties one or another method crosslinking.